LINKIng gut bacteria and joint inflammation in IBD

LINKIng gut bacteria and joint inflammation in IBD



  • DeFilippis EM, Longman R, Harbus M, Dannenberg K, Scherl EJ. Crohn’s Disease: Evolution, Epigenetics, and the Emerging Role of Microbiome-Targeted Therapies. Curr Gastroenterol Rep. 2016 Mar;18(3):13. doi: 10.1007/s11894-016-0487-z. PMID: 26908281


  • Hirten, R, Bosworth, B, Longman, R, Scherl, EJ.  Vedolizumab and Infliximab Combination Therapy in the Treatment of Crohn’s Disease.  Am J Gastroenterology.  2015 Dec;110(12):1737-8. doi: 10.1038/ajg.2015.355. PMID: 26673509
  • Longman, RS, Littman, DR. Curr Opin Rheumatol (2015), Jul 27(4):381-7. PMID: 26002030
  • Chen, H., Sun, J., Huang, Z., Hou, H., Arcilla, M, Rakhilin, N., Joe, D., Choi, J., Gadamsetty, P., Milsom, J., Nandakumar, G., Longman, R., Zhou, K., Edwards, R., Chen, J., Chen, K., Bu, P. Miller, A., Gümüş, Z., Shuler, M., Nishimura, N., Edelmann, W., Shen, X., Lipkin, SM. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nature Biotechnology 2015; Jun;33(6):656-60. doi: 10.1038/nbt.3239


  • Longman, RS#, Diehl, G, Victorio, D, Huh, J, Miraldi, E, Swaminath, A, Bonneau, R, Scherl, EJ, Littman, DR#. CX3CR1+ Mononuclear Phagocytes Support Colitis-Associated Innate Lymphoid Cell Production of IL-22. J Exp Med 211, 1571-1583, doi:10.1084/jem.20140678 (2014). #  Co-corresponding authors
  • Longman, RS, Scherl, EJ. Medical Management of Extraintestinal Manifestations of Ulcerative Colitis. In G. Lichtenstein (Ed.), Medical Therapy of Mucosal Ulcerative Colitis, New York: Springer, (2014).


  •  Scher, JU*, Sczesnak, A*, Longman, RS*, Segata, N, Ubeda, C, Bielski, C, Rostron, T, Cerundolo, V, Pamer, EG Abramson, SB, Huttenhower, C, Littman, DR. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2013;2:e01202. Doi: 10.7554/eLife.01202  * Contributed equally
  • Longman, RS, Yang, Y, Diehl, GE, Kim, SW, Littman, DR.  Microbiota-Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity, Cold Spring Harb Symp Quant Biol (2013), 78:193-201. PMCID: PMC4367195
  • Diehl, G, Longman, RS, Zhang, J, Breart, B, Galan, C, Cuesta, A, Schwab, S, Littman, DR. Microbiota-Derived Signals Limit CX3CR1+ Cell-Dependent Trafficking of Bacteria to the Mesenteric Lymph Nodes. Nature, Feb 7;494(7435):116-20. doi: 10.1038/nature11809. Epub 2013 Jan 13. PubMed PMID: 23334413.


  • Decalf, J, Fernandes, S, Longman, R, Aloulay, M, Audat, F, Lefrerre, F, Rice, CM, Pol, S, Albert, ML. Plasmacytoid DCs initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients.  J. Exp. Med., 204: 2423-2437 (2007). PMCID:PMC2118448
  • Longman, RS, Pellegrini, S, Rice, CM, Darnell, RB, Albert, ML. Dendritic cell maturation alters intracellular signaling networks, enabling differential effects of IFNa/b on antigen cross-presentation. Blood 109: 1113-1122 (2007). PMID:17018853
  • Barba-Spaeth, G*, Longman, RS*, Albert, ML, Rice, CM. Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes. J. Exp Med. 202:1179-1184 (2005). PMCID: PMC2213233* Contributed equally
  • Longman, RS, Talal, A, Jacobson, I, Rice, CM, Albert, ML. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patient with chronic hepatitis C. J. Infect. Dis. 192: 497-503 (2005). PMID:15995965
  • Braun, D, Longman, RS, Albert, ML. A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood 106:2375-2381 (2005). PMCID:PMC1895261
  • Longman, RS, Talal, A, Jacobson, I, Albert, ML, Rice, CM. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 103:1026-1029 (2004). PMID:14525790
  • Stathopoulos, C., Jacquin-Becker, C., Becker, H.D., Li, T., Ambrogelly, A., Longman, R. and Söll, D. Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites. Biochemistry 40: 46-52 (2001). PMID:11141055
  • Stathopoulos, C., Li, T., Longman, R., Vothknecht, U.C., Becker, H., Ibba, M. and Söll, D. One polypeptide with two aminoacyl-tRNA synthetase activities. Science 287: 479-482 (2000). PMID:1064254